Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen.

Schepers, Arnout; Jochems, Fleur; Lieftink, Cor; Wang, Liqin; Pogacar, Ziva; Leite de Oliveira, Rodrigo; De Conti, Giulia; Beijersbergen, Roderick L; Bernards, Rene

Schepers, Arnout; Jochems, Fleur; Lieftink, Cor; Wang, Liqin; Pogacar, Ziva; Leite de Oliveira, Rodrigo; De Conti, Giulia; Beijersbergen, Roderick L; Bernards, Rene.

Afiliação

Schepers A; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Jochems F; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Lieftink C; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Wang L; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Pogacar Z; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Leite de Oliveira R; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
De Conti G; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Beijersbergen RL; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Bernards R; Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands. r.bernards@nki.nl.

Mol Cancer Res ; 19(10): 1613-1621, 2021 10.

Article em En | MEDLINE | ID: mdl-34158393

Assuntos

Proteínas Relacionadas à Autofagia/genética; Autofagia/genética; Sistemas CRISPR-Cas/genética; Senescência Celular/genética; Células A549; Apoptose/efeitos dos fármacos; Apoptose/genética; Autofagia/efeitos dos fármacos; Proteína Homóloga à Proteína-1 Relacionada à Autofagia/genética; Sistemas CRISPR-Cas/efeitos dos fármacos; Linhagem Celular; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Proliferação de Células/genética; Senescência Celular/efeitos dos fármacos; Células HEK293; Humanos; Neoplasias/tratamento farmacológico; Neoplasias/genética; Bibliotecas de Moléculas Pequenas/farmacologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Senescência Celular / Sistemas CRISPR-Cas / Proteínas Relacionadas à Autofagia Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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