Advances in the mechanism and treatment of mitochondrial quality control involved in myocardial infarction.
J Cell Mol Med
; 25(15): 7110-7121, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-34160885
ABSTRACT
Mitochondria are important organelles in eukaryotic cells. Normal mitochondrial homeostasis is subject to a strict mitochondrial quality control system, including the strict regulation of mitochondrial production, fission/fusion and mitophagy. The strict and accurate modulation of the mitochondrial quality control system, comprising the mitochondrial fission/fusion, mitophagy and other processes, can ameliorate the myocardial injury of myocardial ischaemia and ischaemia-reperfusion after myocardial infarction, which plays an important role in myocardial protection after myocardial infarction. Further research into the mechanism will help identify new therapeutic targets and drugs for the treatment of myocardial infarction. This article aims to summarize the recent research regarding the mitochondrial quality control system and its molecular mechanism involved in myocardial infarction, as well as the potential therapeutic targets in the future.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Mitocôndrias Cardíacas
/
Infarto do Miocárdio
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article