BlackSheep: A Bioconductor and Bioconda Package for Differential Extreme Value Analysis.
J Proteome Res
; 20(7): 3767-3773, 2021 07 02.
Article
em En
| MEDLINE
| ID: mdl-34165986
ABSTRACT
Unbiased assays such as shotgun proteomics and RNA-seq provide high-resolution molecular characterization of tumors. These assays measure molecules with highly varied distributions, making interpretation and hypothesis testing challenging. Samples with the most extreme measurements for a molecule can reveal the most interesting biological insights yet are often excluded from analysis. Furthermore, rare disease subtypes are, by definition, underrepresented in cancer cohorts. To provide a strategy for identifying molecules aberrantly enriched in small sample cohorts, we present BlackSheep, a package for nonparametric description and differential analysis of genome-wide data, available from Bioconductor (https//www.bioconductor.org/packages/release/bioc/html/blacksheepr.html) and Bioconda (https//bioconda.github.io/recipes/blksheep/README.html). BlackSheep is a complementary tool to other differential expression analysis methods, which is particularly useful when analyzing small subgroups in a larger cohort.
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2021
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Article