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Prescribing Tamoxifen in Patients With Mood Disorders: A Systematic Review of Potential Antimanic Versus Depressive Effects.
Carmassi, Claudia; Cordone, Annalisa; Dell'Oste, Valerio; Pedrinelli, Virginia; Pardini, Francesco; Simoncini, Marly; Dell'Osso, Liliana.
Afiliação
  • Carmassi C; From the Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Cordone A; From the Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Pedrinelli V; From the Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Pardini F; From the Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Simoncini M; From the Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Dell'Osso L; From the Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
J Clin Psychopharmacol ; 41(4): 450-460, 2021.
Article em En | MEDLINE | ID: mdl-34166298
PURPOSE/BACKGROUND: Tamoxifen is a selective estrogen receptor modulator widely used for treatment and prevention of estrogenic receptor-positive breast cancer. Tamoxifen is an object of growing interest in psychopharmacology as an antimanic drug, because it inhibits the protein kinase C, a molecular target of bipolar disorder. Consistently, the potential depressive effect of tamoxifen has been repeatedly reported. METHODS/PROCEDURES: This article systematically reviews studies examining tamoxifen impact on mood, exploring either its potential therapeutic use as antimanic agent or its potential depressive effect. FINDINGS: Eight studies explored tamoxifen antimanic properties, all, but one, reported a rapid and efficacious antimanic action. As to the depressive effect, 9 cohort studies emerged among which 4 pointed out an increased risk of depression. Seven case reports described the onset or exacerbation of depressive episodes besides 1 case series study reported a high rate of depressive symptoms. In addition, 1 case report study described a tamoxifen-induced manic episode. IMPLICATIONS/CONCLUSIONS: The present review highlights tamoxifen treatment as a possible trigger of mood symptoms onset or exacerbation in vulnerable patients. Accordingly, patients with a history of mood disorders may require a close clinical surveillance during tamoxifen use. At the same time, the use of tamoxifen as an antimanic agent in psychiatric settings requires caution, as available evidence came from small-sample studies with short observation time. More studies are needed to define how long-term tamoxifen use may affect the course of bipolar disorder.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tamoxifeno / Transtorno Bipolar / Depressão Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tamoxifeno / Transtorno Bipolar / Depressão Idioma: En Ano de publicação: 2021 Tipo de documento: Article