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Cardiac performance in heat-stressed flies of heat-susceptible and heat-resistant Drosophila melanogaster.
Rodríguez, Maia; Pagola, Lucía; Norry, Fabian M; Ferrero, Paola.
Afiliação
  • Rodríguez M; Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino 2700, Buenos Aires, Argentina.
  • Pagola L; Centro de Investigaciones Cardiovasculares 'Dr. Horacio E. Cingolani', Facultad de Ciencias Médicas, UNLP, La Plata 1900, Buenos Aires, Argentina.
  • Norry FM; Facultad de Ciencias Exactas y Naturales, Departamento de Ecología, Genética y Evolución, Universidad de Buenos Aires, C-1428-EHA Buenos Aires, Argentina; Instituto de Ecología, Genética y Evolución de Buenos Aires (IEGEBA) - CONICET, Universidad de Buenos Aires, C-1428-EHA Buenos Aires, Argentina.
  • Ferrero P; Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Pergamino 2700, Buenos Aires, Argentina; Centro de Investigaciones Cardiovasculares 'Dr. Horacio E. Cingolani', Facultad de Ciencias Médicas, UNLP, La Plata 1900, Buenos Aires, Argen
J Insect Physiol ; 133: 104268, 2021.
Article em En | MEDLINE | ID: mdl-34171365
Thermotolerance is a complex trait that can greatly differ between heat-susceptible (HS) and heat-adapted populations of small insects including Drosophila, with short-term effects after a sub-lethal level of heat stress on many physiological functions. Cardiac performance could accordingly be more robust in heat-resistant (HR) than in HS individuals under heat stress. Here, we tested heart performance under heat-stress effects in two recombinant inbred lines (RIL) of Drosophila melanogaster that dramatically differ in heat knockdown resistance. Heart rate did not strongly differ between heat-susceptible and heat-tolerant flies after a sub-lethal heat stress. Instead, heat-susceptible flies showed a much higher arrhythmia incidence, a longer duration of each heartbeat, and a larger amount of bradycardia than heat-tolerant flies. The highly conserved cardiac proteins SERCA, RyR and NCX that participate in the excitation/contraction coupling, did not differ in activity level between HR and HS flies. Available information for both RIL suggests that heart performance under heat stress may be linked, at least partially, to candidate genes of previously identified quantitative trait loci (QTL) for thermotolerance. This study indicates that HR flies can be genetically more robust in their heart performance than HS flies under even sub-lethal levels of heat stress.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resposta ao Choque Térmico / Drosophila melanogaster / Coração Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resposta ao Choque Térmico / Drosophila melanogaster / Coração Idioma: En Ano de publicação: 2021 Tipo de documento: Article