ANXA1 with Anti-Inflammatory Properties Might Contribute to Parkinsonism.
Ann Neurol
; 90(2): 319-323, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-34180078
ABSTRACT
We here describe the identification of a novel variant in the anti-inflammatory Annexin A1 protein likely to be the cause of disease in two siblings with autosomal recessive parkinsonism. The disease-segregating variant was ascertained through a combination of homozygosity mapping and whole genome sequencing and was shown to impair phagocytosis in zebrafish mutant embryos. The highly conserved variant, absent in healthy individuals and public SNP databases, affected a functional domain of the protein with neuroprotective properties. This study supports the hypothesis that damaged microglia might lead to impairments in the clearance of accumulated and aggregated proteins resulting in parkinsonism. ANN NEUROL 2021;90319-323.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Anexinas
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Transtornos Parkinsonianos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article