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A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
Jhun, Min-A; Mendelson, Michael; Wilson, Rory; Gondalia, Rahul; Joehanes, Roby; Salfati, Elias; Zhao, Xiaoping; Braun, Kim Valeska Emilie; Do, Anh Nguyet; Hedman, Åsa K; Zhang, Tao; Carnero-Montoro, Elena; Shen, Jincheng; Bartz, Traci M; Brody, Jennifer A; Montasser, May E; O'Connell, Jeff R; Yao, Chen; Xia, Rui; Boerwinkle, Eric; Grove, Megan; Guan, Weihua; Liliane, Pfeiffer; Singmann, Paula; Müller-Nurasyid, Martina; Meitinger, Thomas; Gieger, Christian; Peters, Annette; Zhao, Wei; Ware, Erin B; Smith, Jennifer A; Dhana, Klodian; van Meurs, Joyce; Uitterlinden, Andre; Ikram, Mohammad Arfan; Ghanbari, Mohsen; Zhi, Deugi; Gustafsson, Stefan; Lind, Lars; Li, Shengxu; Sun, Dianjianyi; Spector, Tim D; Chen, Yii-der Ida; Damcott, Coleen; Shuldiner, Alan R; Absher, Devin M; Horvath, Steve; Tsao, Philip S; Kardia, Sharon; Psaty, Bruce M.
Afiliação
  • Jhun MA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. mina.jhun82@gmail.com.
  • Mendelson M; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. mina.jhun82@gmail.com.
  • Wilson R; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Gondalia R; Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.
  • Joehanes R; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Salfati E; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Zhao X; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
  • Braun KVE; Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Do AN; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Hedman ÅK; The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Zhang T; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  • Carnero-Montoro E; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Shen J; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Bartz TM; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  • Brody JA; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.
  • Montasser ME; GENYO, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain.
  • O'Connell JR; Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.
  • Yao C; Cardiovascular Health Research Unit, Departments of Medicine and Biostatistics, University of Washington, Seattle, WA, USA.
  • Xia R; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Boerwinkle E; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Grove M; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Guan W; Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Liliane P; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Singmann P; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Müller-Nurasyid M; The Brown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Meitinger T; School of Public Health, University of Texas Health Science Center at Houston, Huston, TX, USA.
  • Gieger C; School of Public Health, University of Texas Health Science Center at Houston, Huston, TX, USA.
  • Peters A; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
  • Zhao W; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Ware EB; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Smith JA; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Dhana K; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • van Meurs J; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Uitterlinden A; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Ikram MA; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
  • Ghanbari M; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
  • Zhi D; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Gustafsson S; Institute of Human Genetics, Technical University Munich, Munich, Germany.
  • Lind L; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Li S; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Sun D; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Spector TD; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
  • Chen YI; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Damcott C; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Shuldiner AR; Survey Research Center, Institute for Social Research, Ann Arbor, MI, USA.
  • Absher DM; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
  • Horvath S; Survey Research Center, Institute for Social Research, Ann Arbor, MI, USA.
  • Tsao PS; Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
  • Kardia S; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
  • Psaty BM; Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Nat Commun ; 12(1): 3987, 2021 06 28.
Article em En | MEDLINE | ID: mdl-34183656
ABSTRACT
Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics, respectively, and an additional 186 novel associations through a trans-ethnic meta-analysis. We observe a high concordance in the direction of effects across racial/ethnic groups, a high correlation of effect sizes between high-density lipoprotein and triglycerides, a modest overlap of associations with epigenome-wide association studies of other cardio-metabolic traits, and a largely non-overlap with lipid loci identified to date through genome-wide association studies. Thirty CpGs reached significance in at least 2 racial/ethnic groups including 7 that showed association with the expression of an annotated gene. CpGs annotated to CPT1A showed evidence of being influenced by triglycerides levels. DNA methylation levels of circulating leukocytes show robust and consistent association with blood lipid levels across multiple racial/ethnic groups.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metilação de DNA / Leucócitos / Lipídeos / Lipoproteínas HDL Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metilação de DNA / Leucócitos / Lipídeos / Lipoproteínas HDL Idioma: En Ano de publicação: 2021 Tipo de documento: Article