Your browser doesn't support javascript.
loading
[Molecular and clinical aspects of the effect of cytidyndiphosphocholine on cognitive functions]. / Molekulyarnye i klinicheskie aspekty deistviya tsitidindifosfokholina na kognitivnye funktsii.
Gromova, O A; Torshin, I Yu; Grishina, T R; Demidov, V I; Bogacheva, T E.
Afiliação
  • Gromova OA; Institute of Pharmacoinformatics of the Federal Research Center «Informatics and Control¼ RAS, Moscow, Russia.
  • Torshin IY; Center for storing and analyzing big data of the National Center for Digital Economy of the Federal State Budgetary Educational Institution of Higher Education «Lomonosov Moscow State University¼, Moscow, Russia.
  • Grishina TR; Institute of Pharmacoinformatics of the Federal Research Center «Informatics and Control¼ RAS, Moscow, Russia.
  • Demidov VI; Center for storing and analyzing big data of the National Center for Digital Economy of the Federal State Budgetary Educational Institution of Higher Education «Lomonosov Moscow State University¼, Moscow, Russia.
  • Bogacheva TE; Ivanovo State Medical Academy of the Ministry of Health of Russia, Ivanovo, Russia.
Article em Ru | MEDLINE | ID: mdl-34184483
OBJECTIVE: Systematization of the array of publications on cytidyldiphosphocholine (CDP-choline). MATERIAL AND METHODS: Systematic computer analysis of all currently available publications on CDP-choline (1750 publications in PUBMED) using the topological theory of big data analysis. RESULTS: CDP-choline is essential for acetylcholine biosynthesis, phospholipid metabolism, and DNA methylation. The article describes the effects of CDP-choline on acetylcholinergic and other types of neurotransmission, anti-inflammatory, neuroprotective and neurotrophic effects of CDP-choline. Also, the paper presents the effects of the molecule on lipid metabolism and gene expression within the post-genomic paradigm (in particular, an increase in the expression of nicotinic and muscarinic acetylcholine receptors). The results of fundamental and clinical studies of CDP-choline in the treatment of cognitive impairments associated with cerebral ischemia and neurodegeneration are presented. CONCLUSION: The pharmacological effects of CDP-choline are mediated through multiple molecular mechanisms that contribute to the nootropic action of this molecule.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Transtornos Cognitivos / Nootrópicos Idioma: Ru Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Encefálica / Transtornos Cognitivos / Nootrópicos Idioma: Ru Ano de publicação: 2021 Tipo de documento: Article