Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration.

Marks, Kathryne E; Flaherty, Stephanie; Patterson, Kristen M; Stratton, Matthew; Martinez, Gustavo J; Reynolds, Joseph M

Marks, Kathryne E; Flaherty, Stephanie; Patterson, Kristen M; Stratton, Matthew; Martinez, Gustavo J; Reynolds, Joseph M.

Afiliação

Marks KE; Center for Cancer Cell Biology, Immunology, and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Flaherty S; Center for Cancer Cell Biology, Immunology, and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Patterson KM; Center for Cancer Cell Biology, Immunology, and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Stratton M; Center for Cancer Cell Biology, Immunology, and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Martinez GJ; Center for Cancer Cell Biology, Immunology, and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Reynolds JM; Center for Cancer Cell Biology, Immunology, and Infection, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA; Edward Hines Jr. VA Hospital, Hines, IL, USA. Electronic address: joseph.reynolds@rosalindfranklin.edu.

Cell Rep ; 35(13): 109303, 2021 06 29.

Article em En | MEDLINE | ID: mdl-34192530

Assuntos

Proteínas de Transporte; Movimento Celular; Células Th17; Receptor 2 Toll-Like; Animais; Masculino; Proteínas de Transporte/metabolismo; Diferenciação Celular/genética; Proliferação de Células; Sistema Nervoso Central/patologia; Regulação para Baixo/genética; Encefalomielite Autoimune Experimental/genética; Encefalomielite Autoimune Experimental/imunologia; Encefalomielite Autoimune Experimental/patologia; Interleucina-1beta; Interleucina-23; Camundongos Endogâmicos C57BL; Transdução de Sinais; Células Th17/citologia; Células Th17/imunologia; Receptor 2 Toll-Like/metabolismo; Transcrição Gênica

Palavras-chave

CCL20; CCR6; EAE; IPCEF; Th17 cells; Toll-like receptor 2; Treg cells; autoimmune disease

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Movimento Celular / Receptor 2 Toll-Like / Células Th17 Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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