Mu-opioid receptor agonism differentially alters social behaviour and immediate early gene expression in male adolescent rats prenatally exposed to valproic acid versus controls.

Hughes, Edel M; Calcagno, Patricia; Sanchez, Connie; Smith, Karen; Kelly, John P; Finn, David P; Roche, Michelle

Hughes, Edel M; Calcagno, Patricia; Sanchez, Connie; Smith, Karen; Kelly, John P; Finn, David P; Roche, Michelle.

Afiliação

Hughes EM; Physiology, School of Medicine, National University of Ireland, Galway, Ireland; Galway Neuroscience Centre, National University of Ireland, Galway, Ireland.
Calcagno P; Physiology, School of Medicine, National University of Ireland, Galway, Ireland; Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland.
Sanchez C; Alkermes Inc., Waltham, MA, United States.
Smith K; Alkermes Inc., Waltham, MA, United States.
Kelly JP; Galway Neuroscience Centre, National University of Ireland, Galway, Ireland; Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland.
Finn DP; Galway Neuroscience Centre, National University of Ireland, Galway, Ireland; Pharmacology and Therapeutics, School of Medicine, National University of Ireland, Galway, Ireland; Centre for Pain Research, National University of Ireland, Galway, Ireland.
Roche M; Physiology, School of Medicine, National University of Ireland, Galway, Ireland; Galway Neuroscience Centre, National University of Ireland, Galway, Ireland; Centre for Pain Research, National University of Ireland, Galway, Ireland. Electronic address: Michelle.roche@nuigalway.ie.

Brain Res Bull ; 174: 260-267, 2021 09.

Article em En | MEDLINE | ID: mdl-34197938

Assuntos

Anticonvulsivantes/toxicidade; Expressão Gênica/efeitos dos fármacos; Genes Precoces/efeitos dos fármacos; Efeitos Tardios da Exposição Pré-Natal/genética; Efeitos Tardios da Exposição Pré-Natal/psicologia; Receptores Opioides mu/agonistas; Comportamento Social; Ácido Valproico/toxicidade; Analgésicos Opioides/farmacologia; Animais; Feminino; Genes fos/efeitos dos fármacos; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Masculino; Morfina/farmacologia; Gravidez; Proteínas Proto-Oncogênicas c-jun/biossíntese; Proteínas Proto-Oncogênicas c-jun/genética; Ratos; Ratos Sprague-Dawley

Palavras-chave

3-chamber; Morphine; Mu; Opioids; Sociability; Social novelty preference; Valproate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Efeitos Tardios da Exposição Pré-Natal / Comportamento Social / Expressão Gênica / Ácido Valproico / Genes Precoces / Receptores Opioides mu / Anticonvulsivantes Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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