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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase.
Bertolin, Agustina P; Weissmann, Florian; Zeng, Jingkun; Posse, Viktor; Milligan, Jennifer C; Canal, Berta; Ulferts, Rachel; Wu, Mary; Drury, Lucy S; Howell, Michael; Beale, Rupert; Diffley, John F X.
Afiliação
  • Bertolin AP; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Zeng J; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Posse V; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Milligan JC; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Wu M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Drury LS; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Howell M; High Throughput Screening, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Biochem J ; 478(13): 2425-2443, 2021 07 16.
Article em En | MEDLINE | ID: mdl-34198323
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Avaliação Pré-Clínica de Medicamentos / Bibliotecas de Moléculas Pequenas / RNA-Polimerase RNA-Dependente de Coronavírus / SARS-CoV-2 Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Avaliação Pré-Clínica de Medicamentos / Bibliotecas de Moléculas Pequenas / RNA-Polimerase RNA-Dependente de Coronavírus / SARS-CoV-2 Idioma: En Ano de publicação: 2021 Tipo de documento: Article