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Novel Pyridyl-Oxazole Carboxamides: Toxicity Assay Determination in Fungi and Zebrafish Embryos.
Chen, Shu; Zhang, Dong-Lin; Ren, Chao-Li; Zou, Wen-Qian; Tian, Xiao-Yu; Du, Xiao-Hua; Tan, Cheng-Xia.
Afiliação
  • Chen S; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
  • Zhang DL; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
  • Ren CL; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
  • Zou WQ; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
  • Tian XY; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
  • Du XH; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
  • Tan CX; College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Molecules ; 26(13)2021 Jun 25.
Article em En | MEDLINE | ID: mdl-34202103
Eight novel pyridyl-oxazole carboxamides were evaluated against fungi and displayed good fungicidal activities against Botrytis cinereal and Rhizoctonia solani. Preliminary bioassay results indicated that at 100 mg/L, compounds 6a-6e, 6g and 6h exhibited 100% fungicidal activities against Botrytis cinerea, and the compound 6b to Rhizoctonia solani at 100%. Then, the zebrafish embryo acute toxicity test was performed to assess the toxicity of 6b and 6c. A series of malformations appeared, when the zebrafish embryos were exposed to 6b and 6c, such as delayed yolk sac resorption, significant shortening of body length, pericardial edema, bending spine, lack of melanin, heart hemorrhage, head hemorrhage, delayed swim sac development, yolk malformation and head malformation. In addition, the acute toxicity of 6b to zebrafish embryo is 4.878 mg/L, and 6c is 6.257 mg/L.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rhizoctonia / Peixe-Zebra / Botrytis / Embrião não Mamífero / Imidazóis / Antifúngicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rhizoctonia / Peixe-Zebra / Botrytis / Embrião não Mamífero / Imidazóis / Antifúngicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article