Successful Treatment of Staphylococcus aureus Prosthetic Joint Infection with Bacteriophage Therapy.
Viruses
; 13(6)2021 06 21.
Article
em En
| MEDLINE
| ID: mdl-34205687
ABSTRACT
Successful joint replacement is a life-enhancing procedure with significant growth in the past decade. Prosthetic joint infection occurs rarely; it is a biofilm-based infection that is poorly responsive to antibiotic alone. Recent interest in bacteriophage therapy has made it possible to treat some biofilm-based infections, as well as those caused by multidrug-resistant pathogens, successfully when conventional antibiotic therapy has failed. Here, we describe the case of a 61-year-old woman who was successfully treated after a second cycle of bacteriophage therapy administered at the time of a two-stage exchange procedure for a persistent methicillin-sensitive Staphylococcus aureus (MSSA) prosthetic knee-joint infection. We highlight the safety and efficacy of both intravenous and intra-articular infusions of bacteriophage therapy, a successful outcome with a single lytic phage, and the development of serum neutralization with prolonged treatment.
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Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
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Bacteriófagos
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Artrite Infecciosa
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Infecções Relacionadas à Prótese
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Terapia por Fagos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article