Pharmacokinetics and Molecular Modeling Indicate nAChR&#945;4-Derived Peptide HAEE Goes through the Blood-Brain Barrier.

Zolotarev, Yurii A; Mitkevich, Vladimir A; Shram, Stanislav I; Adzhubei, Alexei A; Tolstova, Anna P; Talibov, Oleg B; Dadayan, Alexander K; Myasoyedov, Nikolai F; Makarov, Alexander A; Kozin, Sergey A

Pharmacokinetics and Molecular Modeling Indicate nAChRα4-Derived Peptide HAEE Goes through the Blood-Brain Barrier.

Zolotarev, Yurii A; Mitkevich, Vladimir A; Shram, Stanislav I; Adzhubei, Alexei A; Tolstova, Anna P; Talibov, Oleg B; Dadayan, Alexander K; Myasoyedov, Nikolai F; Makarov, Alexander A; Kozin, Sergey A.

Afiliação

Zolotarev YA; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Mitkevich VA; Department of Physiologically Active Substances Chemistry, Institute of Molecular Genetics of National Research Center «Kurchatov Institute¼, 123182 Moscow, Russia.
Shram SI; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Adzhubei AA; Department of Physiologically Active Substances Chemistry, Institute of Molecular Genetics of National Research Center «Kurchatov Institute¼, 123182 Moscow, Russia.
Tolstova AP; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Talibov OB; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Dadayan AK; Department of Clinical Pharmacology, Faculty of Common Medicine, Evdokimov Moscow State University of Medicine and Dentistry, 127473 Moscow, Russia.
Myasoyedov NF; Department of Physiologically Active Substances Chemistry, Institute of Molecular Genetics of National Research Center «Kurchatov Institute¼, 123182 Moscow, Russia.
Makarov AA; Department of Physiologically Active Substances Chemistry, Institute of Molecular Genetics of National Research Center «Kurchatov Institute¼, 123182 Moscow, Russia.
Kozin SA; Laboratory of Protein Conformational Polymorphism in Health and Disease, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

Biomolecules ; 11(6)2021 06 18.

Article em En | MEDLINE | ID: mdl-34207317

Assuntos

Peptídeos/farmacologia; Peptídeos/farmacocinética; Receptores Nicotínicos/genética; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/efeitos dos fármacos; Peptídeos beta-Amiloides/metabolismo; Animais; Transporte Biológico; Barreira Hematoencefálica/efeitos dos fármacos; Encéfalo/metabolismo; Modelos Animais de Doenças; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Modelos Moleculares; Fragmentos de Peptídeos/metabolismo; Fragmentos de Peptídeos/farmacologia; Peptídeos/genética; Coelhos; Ratos; Ratos Wistar; Receptores Nicotínicos/fisiologia

Palavras-chave

Alzheimer's disease; LRP1; beta-amyloid; bloodbrain barrier; peptide drug; receptor-mediated transcytosis; α4ß2 nicotinic acetylcholine receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Receptores Nicotínicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Receptores Nicotínicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article