Pharmacokinetics in Zebrafish Embryos (ZFE) Following Immersion and Intrayolk Administration: A Fluorescence-Based Analysis.

Guarin, Marlly; Ny, Annelii; De Croze, Noémie; Maes, Jan; Léonard, Marc; Annaert, Pieter; de Witte, Peter A M

Guarin, Marlly; Ny, Annelii; De Croze, Noémie; Maes, Jan; Léonard, Marc; Annaert, Pieter; de Witte, Peter A M.

Afiliação

Guarin M; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, 3000 Leuven, Belgium.
Ny A; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, 3000 Leuven, Belgium.
De Croze N; L'Oréal Research & Innovation, 93600 Aulnay-sous-Bois, France.
Maes J; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, 3000 Leuven, Belgium.
Léonard M; L'Oréal Research & Innovation, 93600 Aulnay-sous-Bois, France.
Annaert P; Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, 3000 Leuven, Belgium.
de Witte PAM; Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, 3000 Leuven, Belgium.

Pharmaceuticals (Basel) ; 14(6)2021 Jun 16.

Article em En | MEDLINE | ID: mdl-34208572

Palavras-chave

absorption; computational biology; distribution; exposure routes; false-negatives; fish embryo toxicity test (FET); fluorescent compounds; non-compartmental analysis; pharmacokinetics; zebrafish embryo

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article