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Characteristics of Chimeric West Nile Virus Based on the Japanese Encephalitis Virus SA14-14-2 Backbone.
Li, Guohua; Meng, Xianyong; Ren, Zhiguang; Li, Entao; Yan, Feihu; Liu, Jing; Zhang, Ying; Cui, Zhanding; Li, Yuetao; Jin, Hongli; Cao, Zengguo; Yi, Le; Huang, Pei; Chi, Hang; Wang, Hualei; Sun, Weiyang; Wang, Tiecheng; Gao, Yuwei; Zhao, Yongkun; Yang, Songtao; Xia, Xianzhu.
Afiliação
  • Li G; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Meng X; College of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
  • Ren Z; College of Animal Science and Technology, Jilin Agricutural University, Changchun 130118, China.
  • Li E; School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
  • Yan F; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Liu J; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Zhang Y; School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
  • Cui Z; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Li Y; College of Animal Science and Technology, Jilin Agricutural University, Changchun 130118, China.
  • Jin H; College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453003, China.
  • Cao Z; Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
  • Yi L; Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
  • Huang P; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Chi H; Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
  • Wang H; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Sun W; Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China.
  • Wang T; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Gao Y; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Zhao Y; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Yang S; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
  • Xia X; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130122, China.
Viruses ; 13(7)2021 06 29.
Article em En | MEDLINE | ID: mdl-34209472
ABSTRACT
West Nile virus disease (WND) is an arthropod-borne zoonosis responsible for nonspecific fever or severe encephalitis. The pathogen is West Nile virus belonging to the genus Flavivirus, family Flaviviridae. Every year, thousands of cases were reported, which poses significant public health risk. Here, we constructed a West Nile virus chimera, ChiVax-WN01, by replacing the prMΔE gene of JEV SA14-14-2 with that of the West Nile virus NY99. The ChiVax-WN01 chimera showed clear, different characters compared with that of JEV SA14-14-2 and WNV NY99 strain. An animal study indicated that the ChiVax-WN01 chimera presented moderate safety and immunogenicity for 4-week female BALB/c mice.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus do Nilo Ocidental / Quimera / Vírus da Encefalite Japonesa (Espécie) Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus do Nilo Ocidental / Quimera / Vírus da Encefalite Japonesa (Espécie) Idioma: En Ano de publicação: 2021 Tipo de documento: Article