How stereochemistry of lipid components can affect lipid organization and the route of liposome internalization into cells.
Nanoscale
; 13(27): 11976-11993, 2021 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-34212969
ABSTRACT
Though liposome-based drugs are in clinical use, the mechanism of cell internalization of liposomes is yet an object of controversy. The present experimental investigation, carried out on human glioblastoma cells, indicated different internalization routes for two diastereomeric liposomes. Molecular dynamics simulations of the lipid bilayers of the two formulations indicated that the different stereochemistry of a lipid component controls some parameters such as area per lipid molecule and fluidity of lipid membranes, surface potential and water organization at the lipid/water interface, all of which affect the interaction with biomolecules and cell components.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bicamadas Lipídicas
/
Lipossomos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article