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TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related intestinal mucositis and late-onset diarrhoea.
Wong, Deysi Viviana Tenazoa; Holanda, Renata Brito Falcão; Cajado, Aurilene Gomes; Bandeira, Alessandro Maia; Pereira, Jorge Fernando Bessa; Amorim, Joice Oliveira; Torres, Clarice Sampaio; Ferreira, Luana Maria Moura; Lopes, Marina Helena Silva; Oliveira, Roberta Taiane Germano; Pereira, Anamaria Falcão; Sant'Ana, Rosane Oliveira; Arruda, Larissa Mont'alverne; Ribeiro-Júnior, Howard Lopes; Pinheiro, Ronald Feitosa; Almeida, Paulo Roberto Carvalho; Carvalho, Robson Francisco; Chaves, Fábio Figueiredo; Rocha-Filho, Duílio Reis; Cunha, Fernando Queiroz; Lima-Júnior, Roberto César Pereira.
Afiliação
  • Wong DVT; Graduate Program in Pathology, Department of Pathology and Forensic Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Holanda RBF; Laboratory of Molecular Biology and Genetics, Haroldo Juaçaba Hospital, Cancer Institute of Ceará (ICC), Fortaleza, Ceará, Brazil.
  • Cajado AG; Graduate Program in Pharmaceutical Sciences, Department of Pharmacy, Faculty of Pharmacy, Nursing and Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Bandeira AM; Laboratory of Inflammation and Cancer Pharmacology, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Pereira JFB; Laboratory of Inflammation and Cancer Pharmacology, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Amorim JO; Laboratory of Inflammation and Cancer Pharmacology, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Torres CS; Laboratory of Molecular Biology and Genetics, Haroldo Juaçaba Hospital, Cancer Institute of Ceará (ICC), Fortaleza, Ceará, Brazil.
  • Ferreira LMM; Laboratory of Inflammation and Cancer Pharmacology, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Lopes MHS; Laboratory of Inflammation and Cancer Pharmacology, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Oliveira RTG; Graduate Program in Pathology, Department of Pathology and Forensic Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Pereira AF; Cancer Cytogenomic Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Sant'Ana RO; Laboratory of Inflammation and Cancer Pharmacology, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Arruda LM; Laboratory of Molecular Biology and Genetics, Haroldo Juaçaba Hospital, Cancer Institute of Ceará (ICC), Fortaleza, Ceará, Brazil.
  • Ribeiro-Júnior HL; Clinical Oncology Service, Haroldo Juaçaba Hospital, Cancer Institute of Ceará (ICC), Fortaleza, Ceará, Brazil.
  • Pinheiro RF; Clinical Oncology Service, Haroldo Juaçaba Hospital, Cancer Institute of Ceará (ICC), Fortaleza, Ceará, Brazil.
  • Almeida PRC; Cancer Cytogenomic Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Carvalho RF; Cancer Cytogenomic Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Chaves FF; Graduate Program in Pathology, Department of Pathology and Forensic Medicine, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Rocha-Filho DR; Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
  • Cunha FQ; Clinical Oncology Service, Haroldo Juaçaba Hospital, Cancer Institute of Ceará (ICC), Fortaleza, Ceará, Brazil.
  • Lima-Júnior RCP; Clinical Oncology Service, Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Br J Pharmacol ; 178(20): 4193-4209, 2021 10.
Article em En | MEDLINE | ID: mdl-34216140
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diarreia / Mucosite / Receptor Toll-Like 9 / Receptor 4 Toll-Like / Irinotecano Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diarreia / Mucosite / Receptor Toll-Like 9 / Receptor 4 Toll-Like / Irinotecano Idioma: En Ano de publicação: 2021 Tipo de documento: Article