Structural basis for DNA sequence recognition by pioneer factors in nucleosomes.
Curr Opin Struct Biol
; 71: 59-64, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34218163
ABSTRACT
Most of the genomic DNA in eukaryotes is bound to histone complexes, which hinders transcription factors from accessing their target DNA sequences. Here, we discuss recent structural insights into the mechanisms by which pioneer factors, an emerging class of transcription factors, can recognize DNA motifs located on the nucleosome surface.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Nucleossomos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article