1H, 13C, 15N backbone and side-chain chemical shift assignments of the polyketide cyclase from Mycobacterium tuberculosis.
Biomol NMR Assign
; 15(2): 397-402, 2021 10.
Article
em En
| MEDLINE
| ID: mdl-34247331
ABSTRACT
Polyketide cyclase from Mycobacterium tuberculosis (MtPC) is related to the formation of sterol derivatives, which may play a role in immune escape in the initial stage of macrophage infection by Mycobacterium tuberculosis. However, the structure and specific functions of MtPC are still unknown. Here we report the backbone and side-chain NMR resonance assignments for the MtPC. Most resonances were assigned and the secondary structure was predicted according to the assigned backbone resonances by TALOS-N and PECAN. These NMR assignments represent a first step towards researching the structure and function of MtPC.
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Base de dados:
MEDLINE
Assunto principal:
Mycobacterium tuberculosis
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article