Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health.
Mol Metab
; 53: 101290, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34252634
ABSTRACT
OBJECTIVES:
Regular physical exercise improves health by reducing the risk of a plethora of chronic disorders. We hypothesized that endurance exercise training remodels the activity of gene enhancers in skeletal muscle and that this remodeling contributes to the beneficial effects of exercise on human health. METHODS ANDRESULTS:
By studying changes in histone modifications, we mapped the genome-wide positions and activities of enhancers in skeletal muscle biopsies collected from young sedentary men before and after 6 weeks of endurance exercise. We identified extensive remodeling of enhancer activities after exercise training, with a large subset of the remodeled enhancers located in the proximity of genes transcriptionally regulated after exercise. By overlapping the position of enhancers with genetic variants, we identified an enrichment of disease-associated genetic variants within the exercise-remodeled enhancers.CONCLUSION:
Our data provide evidence of a functional link between epigenetic rewiring of enhancers to control their activity after exercise training and the modulation of disease risk in humans.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Músculo Esquelético
/
Epigênese Genética
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Terapia por Exercício
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Treino Aeróbico
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article