Epigenetic Reprogramming of CD4<sup>+</sup> Helper T Cells as a Strategy to Improve Anticancer Immunotherapy.

Renaude, Elodie; Kroemer, Marie; Borg, Christophe; Peixoto, Paul; Hervouet, Eric; Loyon, Romain; Adotévi, Olivier

Epigenetic Reprogramming of CD4⁺ Helper T Cells as a Strategy to Improve Anticancer Immunotherapy.

Renaude, Elodie; Kroemer, Marie; Borg, Christophe; Peixoto, Paul; Hervouet, Eric; Loyon, Romain; Adotévi, Olivier.

Afiliação

Renaude E; University of Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, Besançon, France.
Kroemer M; Centre Hospitalier Universitaire de Besançon, Centre d'Investigation Clinique, INSERM CIC 1431, Besançon, France.
Borg C; University of Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, Besançon, France.
Peixoto P; Department of Pharmacy, University Hospital of Besançon, Besançon, France.
Hervouet E; University of Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, Besançon, France.
Loyon R; Centre Hospitalier Universitaire de Besançon, Centre d'Investigation Clinique, INSERM CIC 1431, Besançon, France.
Adotévi O; Department of Medical Oncology, University Hospital of Besançon, Besançon, France.

Front Immunol ; 12: 669992, 2021.

Article em En | MEDLINE | ID: mdl-34262562

ABSTRACT

ABSTRACT

Evidences highlight the role of various CD4+ helper T cells (CD4+ Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4+ Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4+ T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4+ Th responses by epigenetic drugs to improve anticancer immunotherapy.

Assuntos

Antineoplásicos/uso terapêutico; Reprogramação Celular/efeitos dos fármacos; Epigênese Genética/efeitos dos fármacos; Imunoterapia Adotiva; Linfócitos do Interstício Tumoral/efeitos dos fármacos; Neoplasias/terapia; Linfócitos T Auxiliares-Indutores/efeitos dos fármacos; Linfócitos T Auxiliares-Indutores/transplante; Animais; Antineoplásicos/efeitos adversos; Diferenciação Celular/efeitos dos fármacos; Humanos; Imunoterapia Adotiva/efeitos adversos; Linfócitos do Interstício Tumoral/imunologia; Linfócitos do Interstício Tumoral/metabolismo; Neoplasias/genética; Neoplasias/imunologia; Neoplasias/metabolismo; Linfócitos T Auxiliares-Indutores/imunologia; Linfócitos T Auxiliares-Indutores/metabolismo; Resultado do Tratamento; Microambiente Tumoral

Palavras-chave

CD4+ helper T cells; epigenetics; immunotherapy; plasticity; tumor microenvironment

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoterapia Adotiva / Linfócitos do Interstício Tumoral / Linfócitos T Auxiliares-Indutores / Epigênese Genética / Reprogramação Celular / Neoplasias / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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