Multicomponent T2 relaxometry reveals early myelin white matter changes induced by proton radiation treatment.
Magn Reson Med
; 86(6): 3236-3245, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34268786
ABSTRACT
PURPOSE:
To investigate MRI myelin water imaging (MWI) by multicomponent T2 relaxometry as a quantitative imaging biomarker for brain radiation-induced changes and to compare it with DTI.METHODS:
Sixteen patients underwent fractionated proton therapy (PT) receiving dose to the healthy tissue because of direct or indirect (base skull tumors) irradiation. MWI was performed by a multi-echo sequence with 32 equally spaced echoes (10-320 ms). Decay data were processed to identify 3 T2 compartments myelin water (Mw) below 40 ms, intra-extracellular water (IEw) between 40 and 250 ms, and free water (CSFw) above 250 ms. Both MWI and DTI scans were acquired pre (pre)-treatment and immediately at the end (end) of PT. After image registration, voxel-wise difference maps, obtained by subtracting MWI and DTI pre from those acquired at the end of PT, were compared with the corresponding biological equivalent dose (BED).RESULTS:
Mw difference showed a positive correlation and IEw difference showed a negative correlation with BED considering end-pre changes (P < .01). The changes in CSFw were not significantly correlated with the delivered BED. The changes in DTI data, considering end-pre acquisitions, showed a positive correlation between fractional anisotropy and the delivered BED.CONCLUSION:
MWI might detect early white matter radiation-induced alterations, providing additional information to DTI, which might improve the understanding of the pathogenesis of the radiation damage.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Terapia com Prótons
/
Substância Branca
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article