Prediction of overall survival in patients across solid tumors following atezolizumab treatments: A tumor growth inhibition-overall survival modeling framework.

Chan, Phyllis; Marchand, Mathilde; Yoshida, Kenta; Vadhavkar, Shweta; Wang, Nina; Lin, Alyse; Wu, Benjamin; Ballinger, Marcus; Sternheim, Nitzan; Jin, Jin Y; Bruno, René

Chan, Phyllis; Marchand, Mathilde; Yoshida, Kenta; Vadhavkar, Shweta; Wang, Nina; Lin, Alyse; Wu, Benjamin; Ballinger, Marcus; Sternheim, Nitzan; Jin, Jin Y; Bruno, René.

Afiliação

Chan P; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Marchand M; Certara, Marseille, France.
Yoshida K; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Vadhavkar S; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Wang N; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Lin A; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Wu B; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Ballinger M; Department of Clinical Science, Genentech, Inc., South San Francisco, California, USA.
Sternheim N; Department of Product Development, Genentech, Inc., South San Francisco, California, USA.
Jin JY; Department of Clinical Pharmacology, Genentech, Inc., South San Francisco, California, USA.
Bruno R; Department of Clinical Pharmacology, Genentech/Roche, Marseille, France.

CPT Pharmacometrics Syst Pharmacol ; 10(10): 1171-1182, 2021 10.

Article em En | MEDLINE | ID: mdl-34270868

Assuntos

Anticorpos Monoclonais Humanizados/uso terapêutico; Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico; Inibidores de Checkpoint Imunológico/uso terapêutico; Neoplasias/tratamento farmacológico; Proteína C-Reativa/metabolismo; Ensaios Clínicos Fase II como Assunto; Ensaios Clínicos Fase III como Assunto; Humanos; L-Lactato Desidrogenase/sangue; Contagem de Leucócitos; Contagem de Linfócitos; Neoplasias/sangue; Neoplasias/patologia; Neutrófilos; Modelos de Riscos Proporcionais; Albumina Sérica/metabolismo; Taxa de Sobrevida; Carga Tumoral

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Anticorpos Monoclonais Humanizados / Inibidores de Checkpoint Imunológico / Neoplasias Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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