Knockdown of PYCR1 suppressed the malignant phenotype of human hepatocellular carcinoma cells via inhibiting the AKT pathway activation.

Guo, Jiang; Cheng, Xiaoyan; Tian, Yanjie; Li, Baoming; Zhang, Xiaoli; Gao, Xuesong; An, Yunhe

Guo, Jiang; Cheng, Xiaoyan; Tian, Yanjie; Li, Baoming; Zhang, Xiaoli; Gao, Xuesong; An, Yunhe.

Afiliação

Guo J; Department of Interventional Oncology, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China.
Cheng X; Department of Biotechnology, Beijing Center for Physical and Chemical Analysis, No. 27 Xisanhuan North Road, Beijing 100089, China.
Tian Y; Department of Biotechnology, Beijing Center for Physical and Chemical Analysis, No. 27 Xisanhuan North Road, Beijing 100089, China.
Li B; Department of Biotechnology, Beijing Center for Physical and Chemical Analysis, No. 27 Xisanhuan North Road, Beijing 100089, China.
Zhang X; Department of Biotechnology, Beijing Center for Physical and Chemical Analysis, No. 27 Xisanhuan North Road, Beijing 100089, China.
Gao X; Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, No. 8 Jingshun East Street, Chaoyang District, Beijing 100015, China.
An Y; Department of Biotechnology, Beijing Center for Physical and Chemical Analysis, No. 27 Xisanhuan North Road, Beijing 100089, China. Electronic address: anyunhe_bio@163.com.

Reprod Biol ; 21(3): 100534, 2021 Sep.

Article em En | MEDLINE | ID: mdl-34271243

Assuntos

Carcinoma Hepatocelular/metabolismo; Neoplasias Hepáticas/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Pirrolina Carboxilato Redutases/metabolismo; Apoptose; Carcinoma Hepatocelular/genética; Pontos de Checagem do Ciclo Celular; Linhagem Celular Tumoral; Proliferação de Células; Regulação Neoplásica da Expressão Gênica; Técnicas de Silenciamento de Genes; Humanos; Neoplasias Hepáticas/genética; Proteínas Proto-Oncogênicas c-akt/genética; Pirrolina Carboxilato Redutases/genética; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Transcriptoma; delta-1-Pirrolina-5-Carboxilato Redutase

Palavras-chave

AKT pathway; Apoptosis; Hepatocellular carcinoma; PYCR1; Proliferation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolina Carboxilato Redutases / Carcinoma Hepatocelular / Proteínas Proto-Oncogênicas c-akt / Neoplasias Hepáticas Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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