Self-assembly of photosensitive and radiotherapeutic peptide for combined photodynamic-radio cancer therapy with intracellular delivery of miRNA-139-5p.

Wang, Hanhua; Wang, Ziyi; Chen, Weiwei; Wang, Wencai; Shi, Woda; Chen, Jinzhong; Hang, Ye; Song, Jin; Xiao, Xiao; Dai, Zhenyu

Wang, Hanhua; Wang, Ziyi; Chen, Weiwei; Wang, Wencai; Shi, Woda; Chen, Jinzhong; Hang, Ye; Song, Jin; Xiao, Xiao; Dai, Zhenyu.

Afiliação

Wang H; Dept. of Radiation Oncology, Affiliated Yancheng School of Clinical Medicine of Nanjing Medical University, PR China.
Wang Z; Dept. of Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, PR China.
Chen W; Dept. of Radiation Oncology, Affiliated Yancheng School of Clinical Medicine of Nanjing Medical University, PR China.
Wang W; Dept. of Radiation Oncology, Affiliated Yancheng School of Clinical Medicine of Nanjing Medical University, PR China.
Shi W; Dept. of Radiation Oncology, Affiliated Yancheng School of Clinical Medicine of Nanjing Medical University, PR China.
Chen J; Dept. of Radiation Oncology, Affiliated Yancheng School of Clinical Medicine of Nanjing Medical University, PR China.
Hang Y; Dept. of Radiation Oncology, Affiliated Yancheng School of Clinical Medicine of Nanjing Medical University, PR China.
Song J; Dept. of Radiation Oncology, Affiliated Yancheng School of Clinical Medicine of Nanjing Medical University, PR China.
Xiao X; School of Chemistry and Chemical Engineering, Nanjing University,163 Xianlin Avenue, Nanjing 210023, PR China.
Dai Z; Dept. of Radiology, Affiliated Yancheng School of Clinical Medicine of Nanjing Medical University, PR China. Electronic address: ycsydzy@yeah.net.

Bioorg Med Chem ; 44: 116305, 2021 08 15.

Article em En | MEDLINE | ID: mdl-34273735

Assuntos

Antineoplásicos/farmacologia; Sistemas de Liberação de Medicamentos; MicroRNAs/química; Neoplasias/terapia; Peptídeos/farmacologia; Fotoquimioterapia; Fármacos Fotossensibilizantes/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Relação Dose-Resposta a Droga; Humanos; Radioisótopos do Iodo; Estrutura Molecular; Nanopartículas/química; Peptídeos/síntese química; Peptídeos/química; Processos Fotoquímicos; Fármacos Fotossensibilizantes/síntese química; Fármacos Fotossensibilizantes/química; Relação Estrutura-Atividade

Palavras-chave

Cell-penetrating peptides; Nanoparticle; Photodynamic therapy; Radiotherapy; Tumor; miR-139-5p

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Fotoquimioterapia / Sistemas de Liberação de Medicamentos / Fármacos Fotossensibilizantes / MicroRNAs / Neoplasias / Antineoplásicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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