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A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity.
Le Daré, Brendan; Ferron, Pierre-Jean; Bellamri, Nessrine; Ribault, Catherine; Delpy, Eric; Zal, Franck; Lagente, Vincent; Gicquel, Thomas.
Afiliação
  • Le Daré B; Pharmacy, Pontchaillou University Hospital, F-35000, Rennes, France; Univ Rennes, INSERM, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000, Rennes, France. Electronic address: brendan.le.dare@chu-rennes.fr.
  • Ferron PJ; Univ Rennes, INSERM, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000, Rennes, France.
  • Bellamri N; Univ Rennes, INSERM, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000, Rennes, France.
  • Ribault C; Univ Rennes, INSERM, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000, Rennes, France.
  • Delpy E; Hemarina, Aéropôle Centre, F-29600, Morlaix, France.
  • Zal F; Hemarina, Aéropôle Centre, F-29600, Morlaix, France.
  • Lagente V; Univ Rennes, INSERM, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000, Rennes, France.
  • Gicquel T; Forensic and Toxicology Laboratory, Pontchaillou University Hospital, F-35000, Rennes, France; Univ Rennes, INSERM, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer), F-35000, Rennes, France.
Toxicon ; 200: 87-91, 2021 Sep.
Article em En | MEDLINE | ID: mdl-34274377
ABSTRACT
The amanitins (namely α- and ß-amanitin) contained in certain mushrooms are bicyclic octapeptides that, when ingested, are responsible for potentially lethal hepatotoxicity. M101 is an extracellular hemoglobin extracted from the marine worm Arenicola marina. It has intrinsic Cu/Zn-SOD-like activity and is currently used as an oxygen carrier in organ preservation solutions. Our present results suggest that M101 might be effective in reducing amanitin-induced hepatotoxicity and may have potential for therapeutic development.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Doença Hepática Induzida por Substâncias e Drogas Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxigênio / Doença Hepática Induzida por Substâncias e Drogas Idioma: En Ano de publicação: 2021 Tipo de documento: Article