A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity.
Toxicon
; 200: 87-91, 2021 Sep.
Article
em En
| MEDLINE
| ID: mdl-34274377
ABSTRACT
The amanitins (namely α- and ß-amanitin) contained in certain mushrooms are bicyclic octapeptides that, when ingested, are responsible for potentially lethal hepatotoxicity. M101 is an extracellular hemoglobin extracted from the marine worm Arenicola marina. It has intrinsic Cu/Zn-SOD-like activity and is currently used as an oxygen carrier in organ preservation solutions. Our present results suggest that M101 might be effective in reducing amanitin-induced hepatotoxicity and may have potential for therapeutic development.
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
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Doença Hepática Induzida por Substâncias e Drogas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article