PPP1CA/YAP/GS/Gln/mTORC1 pathway activates retinal Müller cells during diabetic retinopathy.

Guo, Yang; Cang, Xiaomin; Zhu, Linling; Zhu, Manhui; Li, Aihong; Wang, Zhenzhen; Zhang, Yuting; Wang, Xueqin; Song, E

Guo, Yang; Cang, Xiaomin; Zhu, Linling; Zhu, Manhui; Li, Aihong; Wang, Zhenzhen; Zhang, Yuting; Wang, Xueqin; Song, E.

Afiliação

Guo Y; Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Cang X; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, China.
Zhu L; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhu M; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Li A; Department of Neurology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Wang Z; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhang Y; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China.
Wang X; Department of Endocrinology, Affiliated Hospital 2 of Nantong University, Nantong, Jiangsu, China. Electronic address: wangxueqin108@163.com.
Song E; Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: songe@suda.edu.cn.

Exp Eye Res ; 210: 108703, 2021 09.

Article em En | MEDLINE | ID: mdl-34280391

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Retinopatia Diabética/metabolismo; Células Ependimogliais/metabolismo; Glutamato-Amônia Ligase/metabolismo; Glutamina/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Proteína Fosfatase 1/metabolismo; Animais; Western Blotting; Proliferação de Células; Células Cultivadas; Diabetes Mellitus Experimental/metabolismo; Ensaio de Imunoadsorção Enzimática; Glucose/farmacologia; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Microscopia de Fluorescência; Reação em Cadeia da Polimerase em Tempo Real; Transdução de Sinais/fisiologia; Estreptozocina; Proteínas de Sinalização YAP

Palavras-chave

Diabetic retinopathy (DR); Mammalian target of rapamycin complex 1 (mTOR 1); Protein phosphatase 1 catalytic subunit alpha (PPP1CA); Retinal Müller cells (RMCs)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Adaptadoras de Transdução de Sinal / Retinopatia Diabética / Proteína Fosfatase 1 / Células Ependimogliais / Alvo Mecanístico do Complexo 1 de Rapamicina / Glutamina / Glutamato-Amônia Ligase Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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