Letting go: Deep computational modeling insights into pH-dependent calcium affinity.
J Biol Chem
; 297(2): 100974, 2021 08.
Article
em En
| MEDLINE
| ID: mdl-34280436
ABSTRACT
Calcium and other cofactors can feature as key additions to a molecular interface, to the extent that the cofactor is completely buried in the bound state. How can such an interaction be regulated then? The answer By facilitating a switch through an allosteric network. Although a number of unbinding mechanisms are being characterized, an extensive computational study by Joswig et al. reveals a detailed model for the pattern recognition receptor langerin.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lectinas Tipo C
/
Lectinas de Ligação a Manose
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article