Antiviral bioactivity of resveratrol against Zika virus infection in human retinal pigment epithelial cells.
Mol Biol Rep
; 48(7): 5379-5392, 2021 Jul.
Article
em En
| MEDLINE
| ID: mdl-34282543
ABSTRACT
Resveratrol (RES) is a polyphenol with increasing interest for its inhibitory effects on a wide variety of viruses. Zika virus (ZIKV) is an arbovirus which causes a broad spectrum of ophthalmological manifestations in humans. Currently there is no certified therapy or vaccine to treat it, thus it has become a major global health threat. Retinal pigment epithelium (RPE) is highly permissive and susceptible to ZIKV. This work explored the protective effects of RES on ZIKV-infected human RPE cells. RES treatment resulted in a significant reduction of infectious viral particles in infected male ARPE-19 and female hTERT-RPE1 cells. This protection was positively influenced by the action of RES on mitochondrial dynamics. Also, docking studies predicted that RES has a high affinity for two enzymes of the rate-limiting steps of pyrimidine and purine biosynthesis and viral polymerase. This evidence suggests that RES might be a potential antiviral agent to treat ZIKV-induced ocular abnormalities.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Epitélio Pigmentado da Retina
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Zika virus
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Resveratrol
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article