Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing.
Nat Commun
; 12(1): 4399, 2021 07 20.
Article
em En
| MEDLINE
| ID: mdl-34285221
ABSTRACT
The decline of neuronal synapses is an established feature of ageing accompanied by the diminishment of neuronal function, and in the motor system at least, a reduction of behavioural capacity. Here, we have investigated Drosophila motor neuron synaptic terminals during ageing. We observed cumulative fragmentation of presynaptic structures accompanied by diminishment of both evoked and miniature neurotransmission occurring in tandem with reduced motor ability. Through discrete manipulation of each neurotransmission modality, we find that miniature but not evoked neurotransmission is required to maintain presynaptic architecture and that increasing miniature events can both preserve synaptic structures and prolong motor ability during ageing. Our results establish that miniature neurotransmission, formerly viewed as an epiphenomenon, is necessary for the long-term stability of synaptic connections.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Terminações Pré-Sinápticas
/
Transmissão Sináptica
/
Neurônios Motores
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article