The human amniotic fluid stem cell secretome triggers intracellular Ca<sup>2+</sup> oscillations, NF-&#954;B nuclear translocation and tube formation in human endothelial colony-forming cells.

Balducci, Valentina; Faris, Pawan; Balbi, Carolina; Costa, Ambra; Negri, Sharon; Rosti, Vittorio; Bollini, Sveva; Moccia, Francesco

The human amniotic fluid stem cell secretome triggers intracellular Ca²⁺ oscillations, NF-κB nuclear translocation and tube formation in human endothelial colony-forming cells.

Balducci, Valentina; Faris, Pawan; Balbi, Carolina; Costa, Ambra; Negri, Sharon; Rosti, Vittorio; Bollini, Sveva; Moccia, Francesco.

Afiliação

Balducci V; Department of Biology and Biotechnology "Lazzaro Spallanzani", Laboratory of General Physiology, University of Pavia, Pavia, Italy.
Faris P; Department of Biology and Biotechnology "Lazzaro Spallanzani", Laboratory of General Physiology, University of Pavia, Pavia, Italy.
Balbi C; Department of Experimental Medicine (DIMES), University of Genova, Genova, Italy.
Costa A; Department of Experimental Medicine (DIMES), University of Genova, Genova, Italy.
Negri S; Department of Biology and Biotechnology "Lazzaro Spallanzani", Laboratory of General Physiology, University of Pavia, Pavia, Italy.
Rosti V; Laboratory of Biochemistry, Biotechnology and Advanced Diagnostic, Myelofibrosis Study Centre, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Bollini S; Department of Experimental Medicine (DIMES), University of Genova, Genova, Italy.
Moccia F; Department of Biology and Biotechnology "Lazzaro Spallanzani", Laboratory of General Physiology, University of Pavia, Pavia, Italy.

J Cell Mol Med ; 25(16): 8074-8086, 2021 08.

Article em En | MEDLINE | ID: mdl-34288391

Assuntos

Líquido Amniótico/metabolismo; Cálcio/metabolismo; Meios de Cultivo Condicionados/química; Células Endoteliais/fisiologia; NF-kappa B/metabolismo; Secretoma; Células-Tronco/citologia; Líquido Amniótico/química; Células Cultivadas; Células Endoteliais/citologia; Humanos; NF-kappa B/genética; Transporte Proteico; Transdução de Sinais; Células-Tronco/metabolismo

Palavras-chave

Ca2+ signalling; InsP3Rs; NAADP; NF-κB; TRPV4; angiogenesis; endothelial colony-forming cells; human amniotic fluid stem cell secretome; paracrine therapy; tubulogenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco / Cálcio / NF-kappa B / Meios de Cultivo Condicionados / Células Endoteliais / Secretoma / Líquido Amniótico Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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