Structure Simplification of Natural Products as a Lead Generation Approach in Agrochemical Discovery.
J Agric Food Chem
; 69(30): 8324-8346, 2021 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-34289305
ABSTRACT
Natural products (NPs) have a long history as sources of compounds for crop protection. Perhaps a more important role for NPs has been as models and inspiration for the discovery and development of synthetic crop protection compounds. NPs and their synthetic mimics account for 18% of all crop protection compounds, whereas another 38% of all crop protection compounds have a NP that could have served as a model. Because NPs are often complex molecules, have limited availability, or possess structural features that constrain their suitability for use in agricultural settings, a key element in NP-inspired compounds is the simplification of the NP structure to provide a synthetically accessible molecule that possesses the physicochemical properties needed for use in crop protection. Herein we review a series of examples of NP mimics that demonstrate the structural or synthetic simplification of NPs as a guide for the discovery of future NP-inspired agrochemicals focused on fungicides, herbicides, and insecticides.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Fungicidas Industriais
/
Inseticidas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article