Defective monocyte chemotactic responsiveness in patients with active tuberculosis.
Immunol Lett
; 16(1): 39-42, 1987 Oct.
Article
em En
| MEDLINE
| ID: mdl-3428931
ABSTRACT
Monocyte migration was studied in 15 patients with newly diagnosed tuberculosis and 17 healthy control subjects matched for age, sex and ethnic group, using a raft modification of the Boyden chamber. Compared with matched controls, patients with tuberculosis exhibited impaired in vitro monocyte random locomotion and directional locomotion (chemotaxis) in response to 2% casein. However, no correlation was found between in vitro monocyte migration and monocyte count, radiological extent of disease or in vitro dermal reactivity to tuberculin-PPD. The observed defects were corrected during the course of chemotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Monócitos
/
Quimiotaxia de Leucócito
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article