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Global cognitive performance at 4-year follow-up in individuals with atrial fibrillation-findings from The Irish Longitudinal Study on Ageing.
McNicholas, Triona; Tobin, Katy; O'Callaghan, Susan; Kenny, Rose Anne.
Afiliação
  • McNicholas T; The Irish Longitudinal Study on Ageing, Trinity College, Dublin, Ireland.
  • Tobin K; Department of Medical Gerontology, Trinity College, Dublin, Ireland.
  • O'Callaghan S; Mercer's Institute for Successful Ageing, St James's Hospital, Dublin, Ireland.
  • Kenny RA; The Irish Longitudinal Study on Ageing, Trinity College, Dublin, Ireland.
Age Ageing ; 50(6): 2192-2198, 2021 11 10.
Article em En | MEDLINE | ID: mdl-34293085
INTRODUCTION: Atrial fibrillation (AF) has been proposed as a risk factor for cognitive impairment, even in the absence of a history of stroke. This study investigates whether AF is associated with increased risk of cognitive decline in a community-dwelling population of adults over the age of 50. METHODS: Data from the 1st and 3rd waves of The Irish Longitudinal Study on Ageing (TILDA) were used (4-year follow-up period). TILDA is a large prospective cohort study of community-dwelling adults over the age of 50 in Ireland. AF was assessed via electrocardiogram. Global cognitive function was assessed at baseline and follow-up using Montreal Cognitive Assessment (MOCA). Analysis of global cognition was repeated stratifying by age. Mixed-effects Poisson regression was used to assess for change in rate of errors on MOCA and MOCA subdomains. RESULTS: A total of 3,417 participants were included in the study. Results found that participants with AF had a greater increase in rate of errors on MOCA over 4-year follow-up (incident rate ratio (IRR) 1.18; 95% confidence interval (CI) 1.02, 1.37; P-value 0.023). However, this was no longer significant on controlling for age, sex and level of education (IRR 1.08; 95% CI 0.93, 1.25; P-value 0.332). There was no difference when stratifying by age group, or when separating MOCA into subdomains. CONCLUSION: Individuals with AF were more likely to show an increase in rate of errors between waves 1 and 3 (4-year follow-up period) in the TILDA population; however, results were not significant when controlling for age, sex and level of education.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Disfunção Cognitiva Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Disfunção Cognitiva Idioma: En Ano de publicação: 2021 Tipo de documento: Article