Discrete roles for Rad54 and Rdh54 during homologous recombination.

ABSTRACT

Rad54 and Rdh54 are Snf2 DNA motor proteins that function during maintenance of genomic integrity. Though highly related, Rad54 and Rdh54 have different biochemical and genetic functions during maintenance of genomic integrity. Rad54 functions primarily during the homology search and strand invasion steps of homologous recombination, while Rdh54 appears to play a minor role in these processes. More recently it has been shown that Rdh54 functions as a pathway branch point at HR intermediates, and as has a role in cell cycle recovery. Here we will explore recent advances that have improved our understanding of the role these two DNA motor proteins play during DNA repair.