A Readily Available Trifluoromethylation Reagent and Its Difunctionalization of Alkenes.
Org Lett
; 23(15): 6079-6083, 2021 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-34296876
ABSTRACT
Trifluoromethyl substitution is notably popular in pharmaceuticals and agrochemicals; however, trifluoromethylated compounds normally rely on the use of cost-prohibitive or gaseous trifluoromethylating reagents, which diminishes the general applicability of these methods. Herein an efficient trifluoromethylation reagent trifluoromethylsulfonyl-pyridinium salt (TFSP) was reported, which can be readily prepared from cheap and easily available bulk industrial feedstocks. TFSP can generate a trifluoromethyl radical under photocatalysis and realize the effective azido- or cyano-trifluoromethylation reactions of alkenes.
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MEDLINE
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En
Ano de publicação:
2021
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Article