Self-standing, conducting and capacitive biomimetic hybrid nanomembranes for selective molecular ion separation.
Phys Chem Chem Phys
; 23(30): 16157-16164, 2021 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-34297025
ABSTRACT
Hybrid free-standing biomimetic materials are developed by integrating the VDAC36 ß-barrel protein into robust and flexible three-layered polymer nanomembranes. The first and third layers are prepared by spin-coating a mixture of poly(lactic acid) (PLA) and poly(vinyl alcohol) (PVA). PVA nanofeatures are transformed into controlled nanoperforations by solvent-etching. The two nanoperforated PLA layers are separated by an electroactive layer, which is successfully electropolymerized by introducing a conducting sacrificial substrate under the first PLA nanosheet. Finally, the nanomaterial is consolidated by immobilizing the VDAC36 protein, active as an ion channel, into the nanoperforations of the upper layer. The integration of the protein causes a significant reduction of the material resistance, which decreases from 21.9 to 3.9 kΩ cm2. Electrochemical impedance spectroscopy studies using inorganic ions and molecular metabolites (i.e.l-lysine and ATP) not only reveal that the hybrid films behave as electrochemical supercapacitors but also indicate the most appropriate conditions to obtain selective responses against molecular ions as a function of their charge. The combination of polymers and proteins is promising for the development of new devices for engineering, biotechnological and biomedical applications.
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1
Base de dados:
MEDLINE
Assunto principal:
Poliésteres
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Polímeros
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Poliestirenos
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Álcool de Polivinil
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Compostos Bicíclicos Heterocíclicos com Pontes
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Materiais Biomiméticos
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Nanoestruturas
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Canais de Ânion Dependentes de Voltagem
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article