Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-&#954;B/MDR1 pathway.

Shono, Kenji; Mizobuchi, Yoshifumi; Yamaguchi, Izumi; Nakajima, Kohei; Fujiwara, Yuri; Fujihara, Toshitaka; Kitazato, Keiko; Matsuzaki, Kazuhito; Uto, Yoshihiro; Sampetrean, Oltea; Saya, Hideyuki; Takagi, Yasushi

Elevated cellular PpIX potentiates sonodynamic therapy in a mouse glioma stem cell-bearing glioma model by downregulating the Akt/NF-κB/MDR1 pathway.

Shono, Kenji; Mizobuchi, Yoshifumi; Yamaguchi, Izumi; Nakajima, Kohei; Fujiwara, Yuri; Fujihara, Toshitaka; Kitazato, Keiko; Matsuzaki, Kazuhito; Uto, Yoshihiro; Sampetrean, Oltea; Saya, Hideyuki; Takagi, Yasushi.

Afiliação

Shono K; Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Mizobuchi Y; Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. y.mizobuchi1203@gmail.com.
Yamaguchi I; Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Nakajima K; Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Fujiwara Y; Graduate School of Technology, Industrial and Social Science, Tokushima University, Tokushima, Japan.
Fujihara T; Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Kitazato K; Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Matsuzaki K; Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Uto Y; Graduate School of Technology, Industrial and Social Science, Tokushima University, Tokushima, Japan.
Sampetrean O; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Saya H; Division of Gene Regulation, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
Takagi Y; Department of Neurosurgery, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.

Sci Rep ; 11(1): 15105, 2021 07 23.

Article em En | MEDLINE | ID: mdl-34301977

Assuntos

Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo; Glioma/metabolismo; NF-kappa B/metabolismo; Células-Tronco Neoplásicas/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Protoporfirinas/metabolismo; Ácido Aminolevulínico/farmacologia; Animais; Linhagem Celular Tumoral; Regulação para Baixo/efeitos dos fármacos; Regulação para Baixo/fisiologia; Glioblastoma/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Células-Tronco Neoplásicas/efeitos dos fármacos; Fármacos Fotossensibilizantes/farmacologia; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética; Terapia por Ultrassom/métodos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Protoporfirinas / Células-Tronco Neoplásicas / NF-kappa B / Membro 1 da Subfamília B de Cassetes de Ligação de ATP / Proteínas Proto-Oncogênicas c-akt / Glioma Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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