An overview of the preclinical discovery and development of bamlanivimab for the treatment of novel coronavirus infection (COVID-19): reasons for limited clinical use and lessons for the future.

Tuccori, Marco; Convertino, Irma; Ferraro, Sara; Valdiserra, Giulia; Cappello, Emiliano; Fini, Elisabetta; Focosi, Daniele

Tuccori, Marco; Convertino, Irma; Ferraro, Sara; Valdiserra, Giulia; Cappello, Emiliano; Fini, Elisabetta; Focosi, Daniele.

Afiliação

Tuccori M; Unit of Adverse Drug Reactions Monitoring, University Hospital of Pisa, Unit of Adverse Drug Reactions Monitoring, Pisa, Italy.
Convertino I; Department of Clinical and Experimental Medicine, Unit of Pharmacology and Pharmacovigilance, University of Pisa, Pisa, Italy.
Ferraro S; Department of Clinical and Experimental Medicine, Unit of Pharmacology and Pharmacovigilance, University of Pisa, Pisa, Italy.
Valdiserra G; Department of Clinical and Experimental Medicine, Unit of Pharmacology and Pharmacovigilance, University of Pisa, Pisa, Italy.
Cappello E; Department of Clinical and Experimental Medicine, Unit of Pharmacology and Pharmacovigilance, University of Pisa, Pisa, Italy.
Fini E; Department of Clinical and Experimental Medicine, Unit of Pharmacology and Pharmacovigilance, University of Pisa, Pisa, Italy.
Focosi D; Department of Clinical and Experimental Medicine, Unit of Pharmacology and Pharmacovigilance, University of Pisa, Pisa, Italy.

Expert Opin Drug Discov ; 16(12): 1403-1414, 2021 12.

Article em En | MEDLINE | ID: mdl-34304682

Assuntos

Anticorpos Monoclonais Humanizados/uso terapêutico; Anticorpos Neutralizantes/uso terapêutico; Tratamento Farmacológico da COVID-19; Desenvolvimento de Medicamentos; Anticorpos Monoclonais Humanizados/administração & dosagem; Anticorpos Neutralizantes/administração & dosagem; COVID-19/terapia; COVID-19/virologia; Humanos; Imunização Passiva; Pandemias; SARS-CoV-2/efeitos dos fármacos; Soroterapia para COVID-19

Palavras-chave

Bamlanivimab; covid-19; etesevimib: monoclonal antibody; ly-cov555; pandemic; sars-cov-2; spike protein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Anticorpos Neutralizantes / Anticorpos Monoclonais Humanizados / Desenvolvimento de Medicamentos / Tratamento Farmacológico da COVID-19 Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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