OCTA and Functional Signs of Preclinical Retinopathy in Type 1 Diabetes Mellitus.

ABSTRACT

BACKGROUND AND OBJECTIVE: There is an emerging role for optical coherence tomography angiography (OCTA) in detecting microvasculature changes in diabetic retinopathy (DR). This study aimed to investigate visual functions and OCTA parameters of retinal and choriocapillaris (CC) flow in patients with type 1 diabetes mellitus (T1DM) without apparent DR. PATIENTS AND METHODS: Patients and age-matched healthy volunteers were enrolled. All participants underwent low-luminance visual acuity assessment, OCT, and OCTA. Assessed OCTA parameters included foveal avascular zone area, acircularity index, vessel density (VD), skeletonized density, and CC flow deficits. RESULTS: Low-luminance deficit (LLD) was significantly higher in patients with diabetes mellitus and correlated with skeletonized density and VD in the superficial vascular plexus (SVP). In the T1DM group, vessel density and skeletonized density were reduced in the SVP and deep capillary plexus. Flow deficits density and the mean size of the flow deficits were increased in patients with T1DM. CONCLUSION: Functional and microvasculature changes were observed at the preclinical stage of DR. Correlation of LLD and OCTA parameters can be a sign of early neurovascular impairment. [Ophthalmic Surg Lasers Imaging Retina. 2021;52S30-S34.].