Advances in chemical proteomic evaluation of lipid kinases-DAG kinases as a case study.
Curr Opin Chem Biol
; 65: 101-108, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-34311404
ABSTRACT
Advancements in chemical proteomics and mass spectrometry lipidomics are providing new opportunities to understand lipid kinase activity, specificity, and regulation on a global cellular scale. Here, we describe recent developments in chemical biology of lipid kinases with a focus on those members that phosphorylate diacylglycerols. We further discuss future implications of how these mass spectrometry-based approaches can be adapted for studies of additional lipid kinase members with the aim of bridging the gap between protein and lipid kinase-focused investigations.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diacilglicerol Quinase
/
Proteômica
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article