Your browser doesn't support javascript.
loading
Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells.
Tian, Ying; Zhang, Fan; Qiu, Yefeng; Wang, Shuang; Li, Feng; Zhao, Jiawei; Pan, Chao; Tao, Yong; Yu, Di; Wei, Wei.
Afiliação
  • Tian Y; Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, P. R. China.
  • Zhang F; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P. R. China.
  • Qiu Y; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P. R. China.
  • Wang S; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-Sen University, Shenzhen, P. R. China.
  • Li F; Animal Center of the Academy of Military Medical Sciences, Beijing, P. R. China.
  • Zhao J; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P. R. China.
  • Pan C; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P. R. China.
  • Tao Y; School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, P. R. China.
  • Yu D; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, P. R. China.
  • Wei W; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, P. R. China.
Nat Biomed Eng ; 5(9): 968-982, 2021 09.
Article em En | MEDLINE | ID: mdl-34312509
Choroidal neovascularization induced by age-related macular degeneration and retinal neovascularization induced by diabetic retinopathy-two leading causes of blindness-are often treated using antibodies targeting vascular endothelial growth factor (VEGF). Here we report a strong association between inflammation and high VEGF expression in aqueous humour samples from patients with choroidal or retinal neovascularization, and show that intravitreally injected exosomes derived from regulatory T cells and conjugated with an anti-VEGF antibody via a peptide linker that is cleavable by matrix metalloproteinases markedly suppressed ocular neovascularization in mouse and non-human primate models of choroidal neovascularization. The engineered exosomes, which selectively accumulate in the neovascularization lesions, could be adapted for other combination therapies of therapeutic antibodies and anti-inflammatory cargo.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neovascularização de Coroide / Exossomos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neovascularização de Coroide / Exossomos Idioma: En Ano de publicação: 2021 Tipo de documento: Article