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A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation.
Nizami, Sohaib; Millar, Val; Arunasalam, Kanisa; Zarganes-Tzitzikas, Tryfon; Brough, David; Tresadern, Gary; Brennan, Paul E; Davis, John B; Ebner, Daniel; Di Daniel, Elena.
Afiliação
  • Nizami S; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
  • Millar V; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
  • Arunasalam K; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
  • Zarganes-Tzitzikas T; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
  • Brough D; National Phenotypic Screening Centre, Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
  • Tresadern G; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
  • Brennan PE; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
  • Davis JB; Alzheimer's Research UK Oxford Drug Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
  • Ebner D; Target Discovery Institute, NDM Research Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7FZ, UK.
  • Di Daniel E; Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK.
Sci Rep ; 11(1): 15319, 2021 07 28.
Article em En | MEDLINE | ID: mdl-34321581
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Avaliação Pré-Clínica de Medicamentos / Ensaios de Triagem em Larga Escala / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Macrófagos Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Avaliação Pré-Clínica de Medicamentos / Ensaios de Triagem em Larga Escala / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Macrófagos Idioma: En Ano de publicação: 2021 Tipo de documento: Article