Halichonic Acid B, a Rearranged Nitrogenous Bisabolene-Type Sesquiterpene from a Marine Sponge Axinyssa sp.
Chem Pharm Bull (Tokyo)
; 69(8): 802-805, 2021.
Article
em En
| MEDLINE
| ID: mdl-34334525
ABSTRACT
A new rearranged nitrogenous bisabolone-type sesquiterpene, halichonic acid B (1), was isolated from a marine sponge Axinyssa sp. together with halichonic acid (2) and (6R,7S)-7-amino-7,8-dihydro-α-bisabolene (3). The structure of 1 was determined by extensive NMR and MS analyses, revealing an unprecedented carbon framework, and its absolute configuration was elucidated by time-dependent density-functional theory (TDDFT)-based electronic circular dichroism (ECD) spectrum calculation. We propose that 1 and 2 may be biosynthesized in the same pathway, involving the reaction between farnesyl pyrophosphate and glycine, followed by cyclization.
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Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Sesquiterpenos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article