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Dorsal Root Ganglion (DRG) and Chronic Pain.
Berger, Amnon A; Liu, Yao; Possoit, HarLee; Rogers, Anna C; Moore, Warner; Gress, Kyle; Cornett, Elyse M; Kaye, Alan David; Imani, Farnad; Sadegi, Kambiz; Varrassi, Giustino; Viswanath, Omar; Urits, Ivan.
Afiliação
  • Berger AA; Beth Israel Deaconess Medical Center, Department of Anesthesiology, Critical Care, and Pain Medicine, Harvard Medical School, Boston, MA, USA.
  • Liu Y; Beth Israel Deaconess Medical Center, Department of Anesthesiology, Critical Care, and Pain Medicine, Harvard Medical School, Boston, MA, USA.
  • Possoit H; LSU Health Shreveport, School of Medicine, Shreveport, LA, USA.
  • Rogers AC; LSU Health Shreveport, School of Medicine, Shreveport, LA, USA.
  • Moore W; LSU Health Shreveport, School of Medicine, Shreveport, LA, USA.
  • Gress K; Georgetown University School of Medicine, Washington, DC, USA.
  • Cornett EM; LSU Health Shreveport, Department of Anesthesiology, Shreveport, LA, USA.
  • Kaye AD; LSU Health Shreveport, Department of Anesthesiology, Shreveport, LA, USA.
  • Imani F; Pain Research Center, Department of Anesthesiology and Pain Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Sadegi K; Department of Anesthesiology, Zabol University of Medical Sciences, Zabol, Iran.
  • Varrassi G; Paolo ProcacciFoundation, Via Tacito 7, Roma, Italy.
  • Viswanath O; Georgetown University School of Medicine, Washington, DC, USA.
  • Urits I; University of Arizona College of Medicine - Phoenix, Department of Anesthesiology, Phoenix, AZ, USA.
Anesth Pain Med ; 11(2): e113020, 2021 Apr.
Article em En | MEDLINE | ID: mdl-34336621
CONTEXT: Chronic neuropathic pain is a common condition, and up to 11.9% of the population have been reported to suffer from uncontrolled neuropathic pain. Chronic pain leads to significant morbidity, lowered quality of life, and loss of workdays, and thus carries a significant price tag in healthcare costs and lost productivity. dorsal root ganglia (DRG) stimulation has been recently increasingly reported and shows promising results in the alleviation of chronic pain. This paper reviews the background of DRG stimulation, anatomical, and clinical consideration and reviews the clinical evidence to support its use. EVIDENCE ACQUISITION: The DRG span the length of the spinal cord and house the neurons responsible for sensation from the periphery. They may become irritated by direct compression or local inflammation. Glial cells in the DRG respond to nerve injury, producing inflammatory markers and contribute to the development of chronic pain, even after the resolution of the original insult. While the underlying mechanism is still being explored, recent studies explored the efficacy of DRG stimulation and neuromodulation for chronic pain treatment. RESULTS: Several reported cases and a small number of randomized trials were published in recent years, describing different methods of DRG stimulation and neuromodulation with promising results. Though evidence quality is mostly low, these results provide evidence to support the utilization of this technique. CONCLUSIONS: Chronic neuropathic pain is a common condition and carries significant morbidity and impact on the quality of life. Recent evidence supports the use of DRG neuromodulation as an effective technique to control chronic pain. Though studies are still emerging, the evidence appears to support this technique. Further studies, including large randomized trials evaluating DRG modulation versus other interventional and non-interventional techniques, are needed to further elucidate the efficacy of this method. These studies are also likely to inform the patient selection and the course of treatment.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2021 Tipo de documento: Article