Accessing HIV-1 Protease Inhibitors through Visible-Light-Mediated Sequential Photocatalytic Decarboxylative Radical Conjugate Addition-Elimination-Oxa-Michael Reactions.
Org Lett
; 23(16): 6283-6287, 2021 08 20.
Article
em En
| MEDLINE
| ID: mdl-34347496
ABSTRACT
A photocatalytic decarboxylative radical conjugate addition-elimination-oxa-Michael reaction of hydroxyalkylated carboxylic acids with cyclopentenones is developed to construct diverse cyclopentanonyl-fused functionalized 5-7 membered cyclic ethers. The stereoselective synthetic strategy is amenable to substructural variation, establishing a direct total synthetic route to two diastereomers of C3-amino cyclopentyltetrahydrofuranyl-derived potent HIV-1 protease inhibitors with low nanomolar IC50 values.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Carboxílicos
/
HIV-1
/
Inibidores da Protease de HIV
/
Fármacos Anti-HIV
/
Ciclopentanos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article