Development of a small-molecule-based activatable photoacoustic probe.
Methods Enzymol
; 657: 1-19, 2021.
Article
em En
| MEDLINE
| ID: mdl-34353483
ABSTRACT
Photoacoustic (PA) imaging is an emerging imaging modality that combines the advantages of optical imaging and ultrasound imaging. In particular, activatable PA probes, which visualize the presence or the activity of target molecules in terms of a change of the PA signal, are useful tools for functional imaging. In this chapter, we describe the development of small-molecule-based activatable PA probes, focusing on the design and synthesis of PA-MMSiNQ, our recently developed activatable PA probe for HOCl. We also describe the protocols used for evaluation of PA-MMSiNQ with a UV-vis spectrometer and a PA imaging microscope.
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Base de dados:
MEDLINE
Assunto principal:
Técnicas Fotoacústicas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article