Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases.
Cells
; 10(7)2021 07 04.
Article
em En
| MEDLINE
| ID: mdl-34359859
ABSTRACT
Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils. NETs participate in host immune defense by entrapping pathogens. They are pro-inflammatory in function, and they act as an initiator of vascular coagulopathies by providing a platform for the attachment of various coagulatory proteins. NETs are diverse in their ability to alter physiological and pathological processes including infection and inflammation. In this review, we will summarize recent findings on the role of NETs in bacterial/viral infections associated with vascular inflammation, thrombosis, atherosclerosis and autoimmune disorders. Understanding the complex role of NETs in bridging infection and chronic inflammation as well as discussing important questions related to their contribution to pathologies outlined above may pave the way for future research on therapeutic targeting of NETs applicable to specific infections and inflammatory disorders.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema Cardiovascular
/
Armadilhas Extracelulares
/
Infecções
/
Inflamação
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article