Novel N-Substituted 3-Aryl-4-(diethoxyphosphoryl)azetidin-2-ones as Antibiotic Enhancers and Antiviral Agents in Search for a Successful Treatment of Complex Infections.

Glowacka, Iwona E; Grabkowska-Druzyc, Magdalena; Andrei, Graciela; Schols, Dominique; Snoeck, Robert; Witek, Karolina; Podlewska, Sabina; Handzlik, Jadwiga; Piotrowska, Dorota G

Glowacka, Iwona E; Grabkowska-Druzyc, Magdalena; Andrei, Graciela; Schols, Dominique; Snoeck, Robert; Witek, Karolina; Podlewska, Sabina; Handzlik, Jadwiga; Piotrowska, Dorota G.

Afiliação

Glowacka IE; Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.
Grabkowska-Druzyc M; Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.
Andrei G; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Herestraat 49, Box 1030, B-3000 Leuven, Belgium.
Schols D; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Herestraat 49, Box 1030, B-3000 Leuven, Belgium.
Snoeck R; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Herestraat 49, Box 1030, B-3000 Leuven, Belgium.
Witek K; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, ul. Medyczna 9, 30-688 Krakow, Poland.
Podlewska S; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, ul. Medyczna 9, 30-688 Krakow, Poland.
Handzlik J; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Medicinal Chemistry, ul. Smetna 12, 31-343 Krakow, Poland.
Piotrowska DG; Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University, Medical College, ul. Medyczna 9, 30-688 Krakow, Poland.

Int J Mol Sci ; 22(15)2021 Jul 27.

Article em En | MEDLINE | ID: mdl-34360797

Assuntos

Adjuvantes Farmacêuticos/química; Adjuvantes Farmacêuticos/farmacologia; Antivirais/química; Antivirais/farmacologia; Azetidinas/farmacologia; Infecções/tratamento farmacológico; Antibacterianos/química; Antibacterianos/farmacologia; Azetidinas/química; Proteínas de Bactérias/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Coronavirus Humano 229E/efeitos dos fármacos; Citostáticos/química; Citostáticos/farmacologia; Humanos; Vírus da Influenza A Subtipo H1N1/efeitos dos fármacos; Simulação de Dinâmica Molecular; Oxacilina/química; Proteínas de Ligação às Penicilinas/química; Staphylococcus aureus/efeitos dos fármacos; Estereoisomerismo; beta-Lactamases/química

Palavras-chave

MRSA; PBP2a; antibiotic adjuvant; antiviral; cytostatic; molecular docking; molecular dynamics; phosphonates; ß-lactams

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Azetidinas / Adjuvantes Farmacêuticos / Infecções Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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